While I appreciate novel therapeutic options, in this case, I wonder if this therapy might lead to unexpected consequences. If the other articles this week are true, then excessively blocking mast cells and IGE coud raise our risk of severe bacterial infections. We use natural therapies to lower mast cell hyperactivity, we don’t want to “turn things off” completely.
Glenn Cruse, Yuzhi Yin, Tomoki Fukuyama, Avanti Desai, Greer K. Arthur, Wolfgang Bäumer, Michael A. Beaven, Dean D. Metcalfe. Exon skipping of FcεRIβ eliminates expression of the high-affinity IgE receptor in mast cells with therapeutic potential for allergy. Proceedings of the National Academy of Sciences, 2016; 201608520 DOI: 10.1073/pnas.1608520113