When looking at tumor inside a person’s body, far more is occurring under the surface than is easily seen by the untrained eye, even at the cellular level. While the prior blog considered how T cells are hindered by oxidized fats in the tumor, this work by Torcellan et al sought to understand the movement of immune cells in and out of tumors. Using a florescent stain in mouse tumor cells, they determined that immune T cells left the tumor in greater numbers than other immune cells, presumably to search for distant tumor cells. We call such distant spread of a tumor, metastases, which often lead to the worse morbidity and mortality in cancer. If we can modify this tumor targeted search and destroy function of departing immune T cells, we might be able to improve survival rates of the more advanced metastatic cancers with less damage to the patient.
Tommaso Torcellan, Henry R. Hampton, Jacqueline Bailey, Michio Tomura, Robert Brink, Tatyana Chtanova. In vivo photolabeling of tumor-infiltrating cells reveals highly regulated egress of T-cell subsets from tumors. Proceedings of the National Academy of Sciences, 2017; 201618446 DOI: 10.1073/pnas.1618446114
Thanks to Science Daily:
Garvan Institute of Medical Research. “Tumor-trained T cells go on patrol: New insights may shape future immune therapies.” ScienceDaily. ScienceDaily, 15 May 2017. <www.sciencedaily.com/releases/2017/05/170515154817.htm>.